Manish Aghi and Ivan El-Sayed perform a transsphenoidal endoscopic surgery for a pituitary tumor

Recognizing that patients with pituitary disorders need coordinated care from a variety of specialists to ensure the best quality of life, the California Center for Pituitary Disorders (CCPD) at UCSF brings expertise from physicians within the disciplines of neurosurgery, neuroendocrinology, neuroradiology, radiation oncology, neuropathology, neurology, neuro-ophthalmology, and psychiatry.

Drawing of macrophages differentiating into M1 and M2 subtypes in pituitary tumors

Interactions with between immune cells and tumor cells have become a large focus in cancer research. A central question in this field revolves around how monocytes and macrophages differentiate into either an M1 subtype, which supresses cancer progression, or an M2 subtype, which enhances it.

MRIs showing before and after surgery for pituitary adenoma
Endoscopic transsphenoidal surgery offers excellent visualization for a giant pituitary adenoma removed at UCSF. Case study by Manish Aghi, MD, PhD.
Image: The G variant of p53 polymorphism rs1042522 drives proliferation in pituitary adenoma cells

Researchers at UCSF have recently discovered a polymorphism in the gene TP53 that influences the growth of non-functional pituitary adenomas (NFPAs). TP53 is known to be dysregulated in many human cancers, including brain cancers. But there have been few studies to date on how it may fit in to the development of pituitary tumors.